Pando

Free software Pando is a small application that allows you to email any size file for free.

Pando is similar to previously-mentioned services like YouSendIt or Dropload, but Pando is actually a standalone app that runs outsite of your browser with a slick, user-friendly interface.

Pando might be a good substitute for a web-based service like YouSendIt, which requires you to use a browser that might more easily be stopped or closed if you forget that you're uploading a large file.

Pando